Streptokinase in clinical practice

proceedings of a conference held in Edinburgh, 20-21 March 1972
  • 141 Pages
  • 2.50 MB
  • English

Fellowship of Postgraduate Medicine , London
Streptokinase -- therapeutic use -- congre
Other titlesConference on streptokinase in clinical practice.
StatementSponsored by Hoechst Pharmaceuticals. Editorial Committee: L. G. Whitby (et al.
SeriesPostgraduate medical journal -- v. 49, Suppl.Aug., 1973
ContributionsWhitby, L. G, Hoechst Pharmaceuticals.
The Physical Object
Pagination141 p. :
ID Numbers
Open LibraryOL20313191M

Streptase® (streptokinase) DESCRIPTION. Streptase®, Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic is supplied as a lyophilized white powder containing 25 mg cross-linked gelatin polypeptides, 25 mg sodium L-glutamate, sodium hydroxide to adjust pH, and mg Albumin (Human) per vial or infusion bottle.

Intracoronary streptokinase in clinical practice The candidacy for streptokinase (SK) infusion was studied in 95 patients displaying ECG evidence of acute or impending infarction who were catheterized within 5 hours of the onset of chest pain. New York,McGraw-Hill Book Co. Zar Streptokinase in clinical practice book Biostatistical analysis.

Englewood Cliffs, NJ Cited by: Streptokinase (SK) is a thrombolytic medication and enzyme. As a medication it is used to break down clots in some cases of myocardial infarction (heart attack), pulmonary embolism, and arterial thromboembolism. The type of heart attack it is used in is an ST elevation myocardial infarction (STEMI).

It is given by injection into a vein. Side effects include nausea, bleeding, low blood Pregnancy category: US: C (Risk not ruled out). Streptokinase is the least expensive fibrinolytic agent, but unfortunately, its antigenicity and its high incidence of untoward reactions limit its usefulness in the clinical setting.

Uses for streptokinase. Streptokinase is used to dissolve blood clots that have formed in the blood vessels. It is used immediately after symptoms of a heart attack occur to improve patient survival. Streptokinase may also be used to treat blood clots in the lungs (pulmonary embolism) and in the legs (deep venous thrombosis)/ Streptokinase is approved for use in myocardial infarction, pulmonary embolism, deep venous thrombosis, arteriovenous-cannula occlusions, and peripheral arterial occlusions.

30 Streptokinase is an enzyme with a molecular weight of 47 Da 35 derived from the culture filtrate of Lancefield group C 5 β-hemolytic streptococci.

1, Vogel G. () Clinical Use of Streptokinase. In: Markwardt F. (eds) Fibrinolytics and Antifibrinolytics. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol Cited by: 9. Streptokinase is a thrombolytic medication. It activates the fibrinolytic system, leading to the breakdown of thrombi (blood clots) that can block blood vessels.

Thrombolytic therapy with Streptokinase is established practice in the treatment of acute myocardial infarction for more than 40 years. Treatment of deep vein thrombosis. A trial of heparin, streptokinase, and arvin. Br Med J. Mar 29; 1 ()– [PMC free article] Johansson E, Ericson K, Zetterquist S.

Streptokinase treatment of deep venous thrombosis of the lower extremity. Clinical, phlebographic and plethysmographic evaluation of early and late results. Subsequently, a clinical trial performed by Dewar and associates 50 in proved a major setback to the role of streptokinase as a thrombolytic agent and its impending use Streptokinase in clinical practice book the treatment of MI.

The study reported no significant differences between treated and untreated (control) patient groups in electrocardiographic findings, transaminase Cited by:   Over a six-month study in general practice 43 patients were identified whose presenting symptom was chest pain thought to be cardiac in origin.

The median time from the onset of pain to the general practitioner attending was 60 minutes. On the basis of history, examination and initial electrocardiogram these patients were assessed as unlikely or likely to be by: 6. provides accurate and independent information on more t prescription drugs, over-the-counter medicines and natural products.

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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 4 May ), Cerner Multum™ (updated 4 May ), Wolters Kluwer™ 10/ Thrombolytics Used in Clinical Practice Streptokinase Streptokinase is a non-fibrinogen-specific fibrinolytic agent and is a protein which is derived from group a streptococci having a molar mass of 47 kDa and is made up of amino acid residues.

The protein exhibits itsFile Size: KB. Synopsis: Streptokinase 2, a metabolic product of β-haemolytic streptococci of Lancefield group C, is a potent activator of the fibrinolytic enzyme system in the treatment of occlusive vascular disease, its principal mechanism of action is believed to involve the activation of both circulating plasminogen and intrinsic thrombus plasminogen through the formation of an activator complex Cited by: streptokinase [strep″to-ki´nās] an enzyme produced by streptococci that catalyzes the conversion of plasminogen to plasmin.

It is administered intravenously as a thrombolytic agent in the treatment of acute coronary arterial thrombosis, acute pulmonary embolism, deep venous thrombosis, and acute arterial thromboembolism or thrombosis.

It is also. Abstract In a controlled trial of streptokinase in acute myocardial infarction, of patients at 11 European centers were stratified according to clinical severity. Three hundred fifteen pat. Streptokinase Clinical Trials - Find paid clinical trials for Streptokinase and other medications and devices.

Streptokinase Clinical Trials: Look up local research clinics in your phone book and ask (a) if they have any studies openly recruiting healthy volunteers and (b) if you could be entered into their volunteer database. Pilot clinical studies indicated that reperfusion could be achieved in a substantial percentage of patients by lysis of coronary thrombosis with both intracoronary and intravenous streptokinase administration.

Intracoronary thrombolysis was receiving widespread clinical applications but had many limitations. Thrombolytic Therapy with Streptokinase in Acute Ischemic Stroke The Multicenter Acute Stroke Trial — Europe Study Group The members of the study group are listed in the Appendix.

What Is Streptase. Streptase (streptokinase) is an enzyme used in the treatment of heart attack or lung blood clots (pulmonary embolism) as well as leg blood clots (deep venous thrombosis-DVT).The brand name drug Streptase is no longer available in the U.S. Generic versions may be available.

What Are Side Effects of Streptase. or previous therapy with anistreplase or streptokinase (within 5 days–6 mo); may produce resistance because of antibody formation; increased dosagerequirements may be encountered (anistreplase and streptokinase only); Previous therapy withFile Size: KB.

Streptokinase: Is a protein secreted by several streptococci, it can bind & activate human plasminogen to convert to plasmin. Generic name: Streptokinase. Brand (trade) name: Kabikinase, Streptas (names registered medication in Saudi Arabia according to FDA).

Therapeutic class: Thrombolytic enzyme. Pharmacologic class: Tissue Plasminogen.

Details Streptokinase in clinical practice FB2

Comparative clinical trials and cost-effectiveness considerations suggest that streptokinase is the drug of choice for thrombolytic therapy (Mucklow, ; Gillis and Goa, ), but this is debatable (Rouf et al., ; Sane and Little, ; Werf, ). Streptokinase is a nonhuman protein, and its introduction into the circulatory systems can.

Streptokinase is used to dissolve blood clots that have formed in the blood vessels. It is used immediately after symptoms of a heart attack occur to improve patient survival.

This medicine may also be used to treat blood clots in the lungs (pulmonary embolism) and in the legs (deep venous thrombosis). Pharmacotherapeutic group: Streptokinase (antithrombotic agents, enzymes) ATC code: B01A D Biofactor Streptokinase is a highly purified streptokinase derived from β haemolytic streptococci of Lancefield group C.

The activation of the endogenous fibrinolytic system is initiated by the formation of a streptokinase-plasminogen : more than 1/; less than 1/ One patient in each group died during treatment.

Clinical treatment success and need for referral to surgery were the main outcome measures. No difference was observed after 3 days. After 7 days, streptokinase-treated patients had a higher clinical success rate (82 vs.

48%, p = ) and fewer referrals for surgery (45 vs. 9%, p = ).Cited by:   Once is enough Thrombolysis is established treatment in the early management of myocardial infarction, and it reduces 35 day mortality by about a quarter.1 The GUSTO study has suggested some advantage of alteplase (rt-PA) over streptokinase with regard to early patency of the occluded coronary artery.2 In particular, GUSTO has suggested that patients aged less than 75 years Cited by: Two large studies were then set up to investigate conclusively the role of streptokinase in treating AMI.

Description Streptokinase in clinical practice FB2

An Italian collaboration known as GISSI tested the addition of intravenous streptokinase to standard therapy, and a second international study (ISIS-2) tested the effects of streptokinase, aspirin and a combination of the two drugs.

Sleight remembers how the studies came about. The Australian Streptokinase Trial was a randomized, double-blind, placebo-controlled trial, in which streptokinase (SK, million IU IV) was given within 4 hours of stroke onset.

In a subset of 37 patients,99m Tc-labeled D,L-hexamethylpropylene amine oxime single-photon emission computed tomography (SPECT) and/or transcranial Doppler (TCD) studies were performed before and after Cited by: The role of streptokinase as a virulence determinant of streptococcus pyogenes - potential for therapeutic targeting Abstract Streptococcus pyogenes is a major human pathogen responsible for numerous diseases ranging from uncomplicated skin and throat infections to severe, life threatening invasive disease such as necrotising fasciitis.

Treatment of peripheral arterial occlusion with plasminogen-activating drugs, most notably the thrombolytic agents streptokinase and urokinase, has enjoyed wider popularity in Europe than in America. The European literature is replete with reports of their effectiveness in a variety of clinical settings, administered by an assortment of methods.

The American literature has tended to emphasize Author: Peter McCombs.Background and Purpose—Three major randomized controlled trials of streptokinase in acute ischemic stroke were curtailed because of safety concerns. The prospective Thrombolysis in Acute Stroke Pooling Project (TAS-PP) was established to examine the aggregate data .streptokinase (strĕp′tō-kĭn′ās, -āz, -kī′nās, -nāz) n.

A protein, produced by hemolytic streptococci, that converts plasminogen to plasmin and is used as a drug to dissolve blood clots. streptokinase (ˌstrɛptəʊˈkaɪneɪs) n (Biochemistry) an enzyme produced by streptococci that causes the fibrin of certain animal species to.